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KMID : 1812720220040020110
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International Journal of Heart Failure
2022 Volume.4 No. 2 p.110 ~ p.116
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Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design
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Cho Dong-Hyuk
Son Jung-Woo
Lee Chan-Joo
Choi Ji-Mi
Kim Mi-Na
Lee Ju-Hee
Lee Sun-Ki
Yang Dong-Heon
Cho Hyun-Jai
Choi Jin-Oh
Kim Eung-Ju
Choi Dong-Ju
Yoo Byung-Su
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Abstract
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Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated HF are scarce. We aim to evaluate the prognostic value of short-term follow-up of surrogate biomarkers for predicting the prognosis of hospitalized patients with acute decompensated HF. This multi-center, prospective study will enroll consecutive hospitalized patients with acute decompensated HF. All patients will undergo sampling and comparison of biomarkers, including plasma N-terminal pro-brain natriuretic peptide, growth differentiation factor 15, troponin-T, high-sensitivity C-reactive protein, and urinary albumin/creatinine ratio obtained within 1 month and 6 months after discharge from the index admission. The primary endpoint is a composite of cardiovascular mortality or HF hospitalization during 1 year of follow-up. We will investigate the prognostic value of multiple biomarkers for the primary endpoint. This trial will provide robust evidence for novel multi-biomarker strategies for acute decompensated HF in real-world settings.
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KEYWORD
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Biomarkers, Heart failure
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